Join us on Saturday, December 7, 2025 for St. Jude Memphis Marathon Weekend presented by Juice Plus+. Choose the marathon, half marathon, 10K, 5K, or take on the 2-Race Challenge. Select your distance and join runners from across the country to support St. Jude kids!

St. Jude Memphis Marathon Weekend is the largest single-day fundraiser for St. Jude Children’s Research Hospital. Families never receive a bill from St. Jude for treatment, travel, housing or food — so they can focus on helping their child live.

Runners in the Marathon start in the iconic and lively Beale Street district and finish with a downhill on Union Ave. adjacent to the finish festival in AutoZone Park. The return of Riverside Drive and the stunning Tom Lee Park gives runners an amazing view of the revitalized Mississippi Riverfront and the Hernando de Soto bridge. Inspiration comes during the run through the St. Jude campus and mission moments then onto historic neighborhoods, through lively block parties, and one-loop through Overton Park.